GMS 6121 Infectious Diseases
Syllabus: Click Here
GMS 6121 is an entry-level graduate course aimed at Microbiology and Cell Science MS students. The goal of this course is to provide a broad overview of infectious pathogens that cause human disease, with a particular emphasis on viral and bacterial pathogens. Furthermore, the course is designed to enable students to gain a fundamental understanding of the principles and mechanisms of microbial pathogenesis. In general, individual lectures will cover (a) general classification and common molecular features of a family of pathogens, and (b) specific mechanisms by which a representative pathogen or pathogens within the family cause disease. The course will be taught by three experienced microbiologists that run viral and bacterial pathogenesis laboratories.
Prerequisite Knowledge and Skills:
General biology, biochemistry, and cell biology.
Course Goals and/or Objectives:
The goal of this course is to provide a broad overview of infectious pathogens that cause human disease, with a particular emphasis on viral and bacterial pathogens. Furthermore, the course is designed to enable students to gain a fundamental understanding of the principles and mechanisms of microbial pathogenesis.
Lectures will be posted each Monday, Wednesday and Friday by 12:00 pm. Each lecture will be divided into 2 to 5 segments. Prior to lecture deadlines (typically Monday at 11:59 am for the prior weeks lectures), students will be expected to view the appropriate online segment, and then take a short, open-book quiz reviewing key objectives that were covered. Approximately 3 class periods will be devoted to current infectious disease “hot” topics and associated scientific papers. In these cases, it is expected that students read the appropriate papers and participate in online discussions as indicated for the specific lecture.
- Introduction and Pathogenesis Overview
- Virus Structure and Classification
- Laboratory Virology and Viral Genetics
- Picornaviruses, Calici- and Astroviruses
- Toga- and Flaviviruses
- Influenza virus
- Discussion: Engineering Superviruses
- Discussion: SARS and MERS coronaviruses
- Mononegavirales, Reoviruses
- Discussion: Ebola virus
- Reverse-transcribing Viruses: Hepatitis B
- HIV and Hep B, AIDS Pathogenesis
- Papillomavirus, Polyomaviruses
- Poxviruses, Herpesviruses
- Bacterial structure, physiology, and genetics
- Antibiotics and resistance
- Bacterial pathogenesis
- Enteric pathogens – toxin-mediated (Botulism, Staph food intoxication, V. cholerae, EHEC, C.
- Enteric pathogens – invasion (Salmonella and Shigella)
- Discussion: ETEC
- Upper respiratory tract Pathogens (S. pyogenes, Bordetella, C. diphtheriae)
- Lower respiratory tract Pathogens (S. pneumoniae, Legionella, tuberculosis)
- Skin and wound pathogens (Staphylococcus, Pseudomonas, tetanus)
- Bioterrorism and zoonotic pathogens (Anthrax, plague, Lyme disease)
- Discussion: Comparative infections
- Meningitis pathogens (Neisseria meningitis, Haemophilus, Listeria)
- Sexually Transmitted Diseases (T. pallidum, N. gonorrhoeae, Chlamydia)
- Mycology (Epidermophyton and Trichophyton, Histoplasma, Candida)
- Parasitology (Giardia, malaria, T. cruzi, hookworms, tapeworms, schistosomes, bed bug)
General course materials and required reading will be available on the Canvas course website, accessible using your Gatorlink username and password.
Required text for the bacteriology section is:
- Schaechter’s Mechanisms of Microbial Diseases. 5th ed. (Lippincott William & Wilkins) NC Englebert, V Dirita, and TS Dermody.
Appropriate supplemental texts include:
- Bacterial Pathogenesis – A Molecular Approach. 2nd ed. AA Salyers & DD Whitt. (ASM Press)
- Cellular Microbiology. 2nd ed. P Cossart, P Boquet, S Normark, & R Rappuoli. (ASM Press)
- Fundamentals of Molecular Virology, 2nd ed. NH Acheson. (John Wiley & Sons)
Distance Education and UF Online Students enjoy the same library privileges as on-campus students.
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